My Bibliography

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Healthcare burden and resource utilization following pediatric acute respiratory distress syndrome: A secondary analysis of the Collaborative Pediatric Critical Care Research Network ARDS Study. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. . NIHMSID: NIHMS1966338.

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Strober JB, Zuppa A, Brooks-Kayal AR. A 15-year-old with back pain, fever, and leg numbness. Semin Pediatr Neurol. 1999 Sep;6(3):190-4; discussion 194-5. doi: 10.1016/s1071-9091(99)80012-6. PubMed PMID: 10522338.

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Zuppa AF, Helfaer MA, Adamson PC. Propofol pharmacokinetics. Pediatr Crit Care Med. 2003 Jan;4(1):124-5. doi: 10.1097/00130478-200301000-00030. PubMed PMID: 12656563.

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Zuppa AF, Shi H, Adamson PC. Liquid chromatography-electrospray mass spectrometry (LC-MS) method for determination of esmolol concentration in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Nov 5;796(2):293-301. doi: 10.1016/j.jchromb.2003.08.014. PubMed PMID: 14581069.

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Zuppa AF, Tejani SM, Cullen EJ Jr, Nadkarni VM. Plasma Concentrations Following Application of Whole versus Cut Transdermal Clonidine Patches To Critically Ill Children. J Pediatr Pharmacol Ther. 2004 Jan;9(1):43-8. doi: 10.5863/1551-6776-9.1.43. PubMed PMID: 23118690; PubMed Central PMCID: PMC3469148.

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Zuppa AF, Nadkarni VM. Recent developments in the pharmacologic approach to pediatric critical care. Curr Opin Anaesthesiol. 2004 Jun;17(3):223-8. doi: 10.1097/00001503-200406000-00005. PubMed PMID: 17021555.

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Zuppa AF, Nadkarni V, Davis L, Adamson PC, Helfaer MA, Elliott MR, Abrams J, Durbin D. The effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function. Crit Care Med. 2004 Nov;32(11):2318-22. doi: 10.1097/01.ccm.0000146133.52982.17. PubMed PMID: 15640648.

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Zuppa AF, Adamson PC, Mondick JT, Davis LA, Maka DA, Narayan M, Nicholson C, Patel D, Collison KR, Barrett JS. Drug utilization in the pediatric intensive care unit: monitoring prescribing trends and establishing prioritization of pharmacotherapeutic evaluation of critically ill children. J Clin Pharmacol. 2005 Nov;45(11):1305-12. doi: 10.1177/0091270005280966. PubMed PMID: 16239364.

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Zuppa AF, Nicolson SC, Adamson PC, Wernovsky G, Mondick JT, Burnham N, Hoffman TM, Gaynor JW, Davis LA, Greeley WJ, Spray TL, Barrett JS. Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction. Anesth Analg. 2006 Apr;102(4):1062-9. doi: 10.1213/01.ane.0000198626.67391.34. PubMed PMID: 16551899.

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Su F, Zuppa AF, Adamson PC. Untying the Gordian knot. Anesth Analg. 2007 Apr;104(4):993; author reply 993-4. doi: 10.1213/01.ane.0000256003.55418.f0. PubMed PMID: 17377125.

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Lee JI, Su F, Shi H, Zuppa AF. Sensitive and specific liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in pediatric plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):195-201. doi: 10.1016/j.jchromb.2007.01.013. Epub 2007 Jan 18. PubMed PMID: 17267303.

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Zuppa A, Vijayakumar S, Jayaraman B, Patel D, Narayan M, Vijayakumar K, Mondick JT, Barrett JS. An informatics approach to assess pediatric pharmacotherapy: design and implementation of a hospital drug utilization system. J Clin Pharmacol. 2007 Sep;47(9):1172-80. doi: 10.1177/0091270007304105. Epub 2007 Jul 26. PubMed PMID: 17656617.

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Zuppa AF, Barrett JS. Pharmacokinetics and pharmacodynamics in the critically ill child. Pediatr Clin North Am. 2008 Jun;55(3):735-55, xii. doi: 10.1016/j.pcl.2008.02.017. Review. PubMed PMID: 18501763.

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Barrett JS, Patel D, Jayaraman B, Narayan M, Zuppa A. Key performance indicators for the assessment of pediatric pharmacotherapeutic guidance. J Pediatr Pharmacol Ther. 2008 Jul;13(3):141-55. doi: 10.5863/1551-6776-13.3.141. PubMed PMID: 23055875; PubMed Central PMCID: PMC3462038.

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Zuppa AF, Mondick JT, Davis L, Cohen D. Population pharmacokinetics of ketorolac in neonates and young infants. Am J Ther. 2009 Mar-Apr;16(2):143-6. doi: 10.1097/MJT.0b013e31818071df. PubMed PMID: 19300040.

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Su F, Nicolson SC, Gastonguay MR, Barrett JS, Adamson PC, Kang DS, Godinez RI, Zuppa AF. Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesth Analg. 2010 May 1;110(5):1383-92. doi: 10.1213/ANE.0b013e3181d783c8. PubMed PMID: 20418300; PubMed Central PMCID: PMC3041635.

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Marsenic O, Zhang L, Zuppa A, Barrett JS, Pfister M. Application of Individualized Bayesian Urea Kinetic Modeling to pediatric hemodialysis. ASAIO J. 2010 May-Jun;56(3):246-53. doi: 10.1097/MAT.0b013e3181cf07d2. PubMed PMID: 20168209.

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Barrett JS, Narayan M, Patel D, Zuppa AF, Adamson PC. Prescribing habits and caregiver satisfaction with resources for dosing children: rationale for more informative dosing guidance. BMC Pediatr. 2011 Apr 2;11:25. doi: 10.1186/1471-2431-11-25. PubMed PMID: 21457572; PubMed Central PMCID: PMC3076266.

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Zuppa AF, Nicolson SC, Barrett JS, Gastonguay MR. Population pharmacokinetics of pentobarbital in neonates, infants, and children after open heart surgery. J Pediatr. 2011 Sep;159(3):414-419.e1-3. doi: 10.1016/j.jpeds.2011.04.021. Epub 2011 Jun 12. PubMed PMID: 21665222; PubMed Central PMCID: PMC3157563.

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Zuppa AF, Hammer GB, Barrett JS, Kenney BF, Kassir N, Mouksassi S, Royal MA. Safety and population pharmacokinetic analysis of intravenous acetaminophen in neonates, infants, children, and adolescents with pain or Fever. J Pediatr Pharmacol Ther. 2011 Oct;16(4):246-61. doi: 10.5863/1551-6776-16.4.246. PubMed PMID: 22768009; PubMed Central PMCID: PMC3385039.

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Zuppa AF. Understanding renal replacement therapy and dosing of drugs in pediatric patients with kidney disease. J Clin Pharmacol. 2012 Jan;52(1 Suppl):134S-40S. doi: 10.1177/0091270011415413. Review. PubMed PMID: 22232749.

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Bratton SL, Newth CJ, Zuppa AF, Moler FW, Meert KL, Berg RA, Berger J, Wessel D, Pollack M, Harrison R, Carcillo JA, Shanley TP, Liu T, Holubkov R, Dean JM, Nicholson CE. Critical care for pediatric asthma: wide care variability and challenges for study. Pediatr Crit Care Med. 2012 Jul;13(4):407-14. doi: 10.1097/PCC.0b013e318238b428. PubMed PMID: 22067984; PubMed Central PMCID: PMC3298633.

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Newth CJ, Meert KL, Clark AE, Moler FW, Zuppa AF, Berg RA, Pollack MM, Sward KA, Berger JT, Wessel DL, Harrison RE, Reardon J, Carcillo JA, Shanley TP, Holubkov R, Dean JM, Doctor A, Nicholson CE. Fatal and near-fatal asthma in children: the critical care perspective. J Pediatr. 2012 Aug;161(2):214-21.e3. doi: 10.1016/j.jpeds.2012.02.041. Epub 2012 Apr 10. PubMed PMID: 22494876; PubMed Central PMCID: PMC3402707.

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Clark AM, Mondick JT, Cloyd JC, Zuppa AF, Raol YH, Clancy RR. Plasma topiramate concentrations resulting from doses associated with neuroprotection against white matter injury and stroke in two strains of rat pups. Pediatr Res. 2013 Mar;73(3):317-24. doi: 10.1038/pr.2012.194. Epub 2012 Dec 19. PubMed PMID: 23254278.

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Berger JT, Carcillo JA, Shanley TP, Wessel DL, Clark A, Holubkov R, Meert KL, Newth CJ, Berg RA, Heidemann S, Harrison R, Pollack M, Dalton H, Harvill E, Karanikas A, Liu T, Burr JS, Doctor A, Dean JM, Jenkins TL, Nicholson CE. Critical pertussis illness in children: a multicenter prospective cohort study. Pediatr Crit Care Med. 2013 May;14(4):356-65. doi: 10.1097/PCC.0b013e31828a70fe. PubMed PMID: 23548960; PubMed Central PMCID: PMC3885763.

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Stricker PA, Zuppa AF, Fiadjoe JE, Maxwell LG, Sussman EM, Pruitt EY, Goebel TK, Gastonguay MR, Taylor JA, Bartlett SP, Schreiner MS. Population pharmacokinetics of epsilon-aminocaproic acid in infants undergoing craniofacial reconstruction surgery. Br J Anaesth. 2013 May;110(5):788-99. doi: 10.1093/bja/aes507. Epub 2013 Jan 25. PubMed PMID: 23353035; PubMed Central PMCID: PMC3695654.

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Costa S, Romagnoli C, Zuppa AA, Cota F, Scorrano A, Gallini F, Maggio L. How to administrate erythropoietin, intravenous or subcutaneous?. Acta Paediatr. 2013 Jun;102(6):579-83. doi: 10.1111/apa.12193. Epub 2013 Feb 25. PubMed PMID: 23414120.

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Su F, Nicolson SC, Zuppa AF. A dose-response study of dexmedetomidine administered as the primary sedative in infants following open heart surgery. Pediatr Crit Care Med. 2013 Jun;14(5):499-507. doi: 10.1097/PCC.0b013e31828a8800. PubMed PMID: 23628837; PubMed Central PMCID: PMC3720685.

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Rizkalla NA, Feudtner C, Dai D, Zuppa AF. Patterns of medication exposures in hospitalized pediatric patients with acute renal failure requiring intermittent or continuous hemodialysis. Pediatr Crit Care Med. 2013 Nov;14(9):e394-403. doi: 10.1097/PCC.0b013e31829f5bc8. PubMed PMID: 23965636.

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Himebauch AS, Zuppa A. Methods for pharmacokinetic analysis in young children. Expert Opin Drug Metab Toxicol. 2014 Apr;10(4):497-509. doi: 10.1517/17425255.2014.885502. Epub 2014 Feb 11. Review. PubMed PMID: 24517202.

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Himebauch AS, Nicolson SC, Sisko M, Moorthy G, Fuller S, Gaynor JW, Zuppa AF, Fox E, Kilbaugh TJ. Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants. J Thorac Cardiovasc Surg. 2014 Dec;148(6):2634-41. doi: 10.1016/j.jtcvs.2014.06.064. Epub 2014 Jul 22. PubMed PMID: 25131168.

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Grimsrud KN, Sherwin CM, Constance JE, Tak C, Zuppa AF, Spigarelli MG, Mihalopoulos NL. Special population considerations and regulatory affairs for clinical research. Clin Res Regul Aff. 2015;32(2):47-56. doi: 10.3109/10601333.2015.1001900. PubMed PMID: 26401094; PubMed Central PMCID: PMC4577021.

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Stricker PA, Gastonguay MR, Singh D, Fiadjoe JE, Sussman EM, Pruitt EY, Goebel TK, Zuppa AF. Population pharmacokinetics of ϵ-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery. Br J Anaesth. 2015 Apr;114(4):689-99. doi: 10.1093/bja/aeu459. Epub 2015 Jan 13. PubMed PMID: 25586726; PubMed Central PMCID: PMC4364063.

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Achuff BJ, Nicolson SC, Elci OU, Zuppa AF. Intraoperative dexmedetomidine reduces postoperative mechanical ventilation in infants after open heart surgery. Pediatr Crit Care Med. 2015 Jun;16(5):440-7. doi: 10.1097/PCC.0000000000000382. PubMed PMID: 25715046.

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Kilbaugh TJ, Himebauch AS, Zaoutis T, Jobes D, Greeley WJ, Nicolson SC, Zuppa AF. A pilot and feasibility study of the plasma and tissue pharmacokinetics of cefazolin in an immature porcine model of pediatric cardiac surgery. Paediatr Anaesth. 2015 Nov;25(11):1111-9. doi: 10.1111/pan.12756. Epub 2015 Sep 15. PubMed PMID: 26372607.

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Berg RA, Nadkarni VM, Clark AE, Moler F, Meert K, Harrison RE, Newth CJ, Sutton RM, Wessel DL, Berger JT, Carcillo J, Dalton H, Heidemann S, Shanley TP, Zuppa AF, Doctor A, Tamburro RF, Jenkins TL, Dean JM, Holubkov R, Pollack MM. Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs. Crit Care Med. 2016 Apr;44(4):798-808. doi: 10.1097/CCM.0000000000001484. PubMed PMID: 26646466; PubMed Central PMCID: PMC4809365.

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Su F, Gastonguay MR, Nicolson SC, DiLiberto M, Ocampo-Pelland A, Zuppa AF. Dexmedetomidine Pharmacology in Neonates and Infants After Open Heart Surgery. Anesth Analg. 2016 May;122(5):1556-66. doi: 10.1213/ANE.0000000000000869. PubMed PMID: 26218862.

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Dai D, Feinstein JA, Morrison W, Zuppa AF, Feudtner C. Epidemiology of Polypharmacy and Potential Drug-Drug Interactions Among Pediatric Patients in ICUs of U.S. Children's Hospitals. Pediatr Crit Care Med. 2016 May;17(5):e218-28. doi: 10.1097/PCC.0000000000000684. PubMed PMID: 26959349; PubMed Central PMCID: PMC5243142.

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Himebauch AS, Sankar WN, Flynn JM, Sisko MT, Moorthy GS, Gerber JS, Zuppa AF, Fox E, Dormans JP, Kilbaugh TJ. Skeletal muscle and plasma concentrations of cefazolin during complex paediatric spinal surgery. Br J Anaesth. 2016 Jul;117(1):87-94. doi: 10.1093/bja/aew032. PubMed PMID: 27317707; PubMed Central PMCID: PMC4913389.

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Himebauch AS, Kilbaugh TJ, Zuppa AF. Pharmacotherapy during pediatric extracorporeal membrane oxygenation: a review. Expert Opin Drug Metab Toxicol. 2016 Oct;12(10):1133-42. doi: 10.1080/17425255.2016.1201066. Epub 2016 Jul 1. Review. PubMed PMID: 27322360.

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Lalley-Chareczko L, Clark D, Zuppa AF, Moorthy G, Conyngham C, Mounzer K, Koenig H. A case study of chewed Truvada(®) for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay. Antivir Ther. 2017;22(7):639-641. doi: 10.3851/IMP3151. Epub 2017 Mar 6. PubMed PMID: 28260694.

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Batra V, Makvandi M, Zuppa AF, Patel N, Elias J, Pryma DA, Maris JM. Dexmedetomidine does not interfere with meta-iodobenzylguanidine (MIBG) uptake at clinically relevant concentrations. Pediatr Blood Cancer. 2017 Apr;64(4). doi: 10.1002/pbc.26268. Epub 2016 Sep 22. PubMed PMID: 27654664.

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Darwich AS, Ogungbenro K, Vinks AA, Powell JR, Reny JL, Marsousi N, Daali Y, Fairman D, Cook J, Lesko LJ, McCune JS, Knibbe C, de Wildt SN, Leeder JS, Neely M, Zuppa AF, Vicini P, Aarons L, Johnson TN, Boiani J, Rostami-Hodjegan A. Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future. Clin Pharmacol Ther. 2017 May;101(5):646-656. doi: 10.1002/cpt.659. Epub 2017 Apr 4. Review. PubMed PMID: 28182269.

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Giaccone A, Zuppa AF, Sood B, Cohen MS, O'Byrne ML, Moorthy G, Mathur A, Kirpalani H. Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2017 Jul;34(8):749-758. doi: 10.1055/s-0036-1597996. Epub 2017 Jan 18. PubMed PMID: 28099979; PubMed Central PMCID: PMC6342009.

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Zane NR, Reedy MD, Gastonguay MR, Himebauch AS, Ramsey EZ, Topjian AA, Zuppa AF. A Population Pharmacokinetic Analysis to Study the Effect of Therapeutic Hypothermia on Vancomycin Disposition in Children Resuscitated From Cardiac Arrest. Pediatr Crit Care Med. 2017 Jul;18(7):e290-e297. doi: 10.1097/PCC.0000000000001198. PubMed PMID: 28481829; PubMed Central PMCID: PMC5503753.

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Koenig HC, Mounzer K, Daughtridge GW, Sloan CE, Lalley-Chareczko L, Moorthy GS, Conyngham SC, Zuppa AF, Montaner LJ, Tebas P. Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis. HIV Med. 2017 Jul;18(6):412-418. doi: 10.1111/hiv.12518. Epub 2017 Apr 26. PubMed PMID: 28444867; PubMed Central PMCID: PMC5459623.

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Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay M, Moorthy GS, Ratshaa BR, Han X, Steenhoff AP, Mosepele M, Strom BL, Aplenc R, Bisson GP, Gross R. Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana. J Acquir Immune Defic Syndr. 2017 Aug 1;75(4):488-491. doi: 10.1097/QAI.0000000000001442. PubMed PMID: 28481785; PubMed Central PMCID: PMC5524513.

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Dalton HJ, Reeder R, Garcia-Filion P, Holubkov R, Berg RA, Zuppa A, Moler FW, Shanley T, Pollack MM, Newth C, Berger J, Wessel D, Carcillo J, Bell M, Heidemann S, Meert KL, Harrison R, Doctor A, Tamburro RF, Dean JM, Jenkins T, Nicholson C. Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation. Am J Respir Crit Care Med. 2017 Sep 15;196(6):762-771. doi: 10.1164/rccm.201609-1945OC. PubMed PMID: 28328243; PubMed Central PMCID: PMC5620676.

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Gross R, Bellamy SL, Ratshaa B, Han X, Vujkovic M, Aplenc R, Steenhoff AP, Mosepele M, Moorthy G, Zuppa AF, Strom BL, Bisson GP. CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana. AIDS. 2017 Sep 24;31(15):2107-2113. doi: 10.1097/QAD.0000000000001593. PubMed PMID: 28692529; PubMed Central PMCID: PMC5612381.

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Zuppa AF, Curley MAQ. Sedation Analgesia and Neuromuscular Blockade in Pediatric Critical Care: Overview and Current Landscape. Pediatr Clin North Am. 2017 Oct;64(5):1103-1116. doi: 10.1016/j.pcl.2017.06.013. Epub 2017 Aug 18. Review. PubMed PMID: 28941538.