My Bibliography

select

Quigley EB, DeVore SB, Khan SA, Geisterfer ZM, Rothfuss HM, Sequoia AO, Thompson PR, Gatlin JC, Cherrington BD, Navratil AM. GnRH Induces Citrullination of the Cytoskeleton in Murine Gonadotrope Cells. Int J Mol Sci. 2024 Mar 10;25(6). doi: 10.3390/ijms25063181. PubMed PMID: 38542155; PubMed Central PMCID: PMC10970285.

select

Yusuf IO, Parsi S, Ostrow LW, Brown RH, Thompson PR, Xu Z. PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS. Neurobiol Dis. 2024 Mar;192:106414. doi: 10.1016/j.nbd.2024.106414. Epub 2024 Jan 21. PubMed PMID: 38253209; PubMed Central PMCID: PMC11003460.

select

Zhu YP, Speir M, Tan Z, Lee JC, Nowell CJ, Chen AA, Amatullah H, Salinger AJ, Huang CJ, Wu G, Peng W, Askari K, Griffis E, Ghassemian M, Santini J, Gerlic M, Kiosses WB, Catz SD, Hoffman HM, Greco KF, Weller E, Thompson PR, Wong LP, Sadreyev R, Jeffrey KL, Croker BA. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. Sci Adv. 2023 Dec 22;9(51):eadj1397. doi: 10.1126/sciadv.adj1397. Epub 2023 Dec 20. PubMed PMID: 38117877; PubMed Central PMCID: PMC10732518.

select

Pasquero S, Gugliesi F, Biolatti M, Dell'Oste V, Albano C, Bajetto G, Griffante G, Trifirò L, Brugo B, Raviola S, Lacarbonara D, Yang Q, Sudeshna S, Barasa L, Haniff H, Thompson PR, Landolfo S, De Andrea M. Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors. PLoS Pathog. 2023 Dec;19(12):e1011849. doi: 10.1371/journal.ppat.1011849. eCollection 2023 Dec. PubMed PMID: 38055760; PubMed Central PMCID: PMC10727434.

select

Geary B, Sun B, Tilvawala RR, Barasa L, Tsoyi K, Rosas IO, Thompson PR, Ho IC. Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA. Front Immunol. 2023;14:1290585. doi: 10.3389/fimmu.2023.1290585. eCollection 2023. PubMed PMID: 38094295; PubMed Central PMCID: PMC10716219.

select

Barasa L, Thompson PR. Protein citrullination: inhibition, identification and insertion. Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220240. doi: 10.1098/rstb.2022.0240. Epub 2023 Oct 2. Review. PubMed PMID: 37778377; PubMed Central PMCID: PMC10542963.

select

Xue T, Fei S, Gu J, Li N, Zhang P, Liu X, Thompson PR, Zhang X. Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells. Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220246. doi: 10.1098/rstb.2022.0246. Epub 2023 Oct 2. PubMed PMID: 37778380; PubMed Central PMCID: PMC10542448.

select

Barasa L, Chaudhuri S, Zhou JY, Jiang Z, Choudhary S, Green RM, Wiggin E, Cameron M, Humphries F, Fitzgerald KA, Thompson PR. Development of LB244, an Irreversible STING Antagonist. J Am Chem Soc. 2023 Sep 20;145(37):20273-20288. doi: 10.1021/jacs.3c03637. Epub 2023 Sep 11. PubMed PMID: 37695732; NIHMSID:NIHMS1985408.

select

Green RM, Thompson PR. Current insights into the role of citrullination in thrombosis. Curr Opin Chem Biol. 2023 Aug;75:102313. doi: 10.1016/j.cbpa.2023.102313. Epub 2023 May 4. Review. PubMed PMID: 37148643; PubMed Central PMCID: PMC10523988.

select

Icso JD, Barasa L, Thompson PR. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Biochemistry. 2023 Jul 4;62(13):2065-2078. doi: 10.1021/acs.biochem.3c00081. Epub 2023 Jun 12. PubMed PMID: 37307562; PubMed Central PMCID: PMC10795796.

select

Ali R, Parelkar SS, Thompson PR, Mitroka-Batsford S, Yerramilli S, Scarlata SF, Mistretta KS, Coburn JM, Mattson AE. Phomoxanthone A Targets ATP Synthase. Chemistry. 2022 Dec 15;28(70):e202202397. doi: 10.1002/chem.202202397. Epub 2022 Oct 25. PubMed PMID: 36082977; PubMed Central PMCID: PMC9942271.

select

Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR. Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045. doi: 10.1021/jacs.2c04626. Epub 2022 Nov 10. PubMed PMID: 36356199; PubMed Central PMCID: PMC9662648.

select

Binder V, Chruścicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P. Carbamylation of Integrin α (IIb) β (3): The Mechanistic Link to Platelet Dysfunction in ESKD. J Am Soc Nephrol. 2022 Oct;33(10):1841-1856. doi: 10.1681/ASN.2022010013. Epub 2022 Aug 29. PubMed PMID: 36038265; PubMed Central PMCID: PMC9528322.

select

Yusuf IO, Qiao T, Parsi S, Tilvawala R, Thompson PR, Xu Z. Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models. Acta Neuropathol Commun. 2022 Sep 8;10(1):135. doi: 10.1186/s40478-022-01433-5. PubMed PMID: 36076282; PubMed Central PMCID: PMC9458309.

select

Icso JD, Thompson PR. The chemical biology of NAD(+) regulation in axon degeneration. Curr Opin Chem Biol. 2022 Aug;69:102176. doi: 10.1016/j.cbpa.2022.102176. Epub 2022 Jul 1. Review. PubMed PMID: 35780654; PubMed Central PMCID: PMC10084848.

select

Peterson ND, Icso JD, Salisbury JE, Rodríguez T, Thompson PR, Pukkila-Worley R. Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition. Elife. 2022 Jan 31;11. doi: 10.7554/eLife.74206. PubMed PMID: 35098926; PubMed Central PMCID: PMC8923663.

select

Tilvawala R, Nemmara VV, Reyes AC, Sorvillo N, Salinger AJ, Cherpokova D, Fukui S, Gutch S, Wagner D, Thompson PR. The role of SERPIN citrullination in thrombosis. Cell Chem Biol. 2021 Dec 16;28(12):1728-1739.e5. doi: 10.1016/j.chembiol.2021.07.009. Epub 2021 Aug 4. PubMed PMID: 34352225; PubMed Central PMCID: PMC8688209.

select

Sen S, Sultana N, Shaffer SA, Thompson PR. Proximity-Dependent Labeling of Cysteines. J Am Chem Soc. 2021 Nov 24;143(46):19257-19261. doi: 10.1021/jacs.1c07069. Epub 2021 Nov 11. PubMed PMID: 34762412; PubMed Central PMCID: PMC8985443.

select

Martín Monreal MT, Rebak AS, Massarenti L, Mondal S, Šenolt L, Ødum N, Nielsen ML, Thompson PR, Nielsen CH, Damgaard D. Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4. Front Immunol. 2021;12:716250. doi: 10.3389/fimmu.2021.716250. eCollection 2021. PubMed PMID: 34737738; PubMed Central PMCID: PMC8560728.

select

Lockbaum GJ, Henes M, Lee JM, Timm J, Nalivaika EA, Thompson PR, Kurt Yilmaz N, Schiffer CA. Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry. 2021 Oct 5;60(39):2925-2931. doi: 10.1021/acs.biochem.1c00414. Epub 2021 Sep 10. PubMed PMID: 34506130; NIHMSID:NIHMS1985500.

select

Maurais AJ, Salinger AJ, Tobin M, Shaffer SA, Weerapana E, Thompson PR. A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination. Biochemistry. 2021 Sep 28;60(38):2902-2914. doi: 10.1021/acs.biochem.1c00369. Epub 2021 Sep 7. PubMed PMID: 34491035; PubMed Central PMCID: PMC8628552.

select

Funabashi K, Sawata M, Nagai A, Akimoto M, Mashimo R, Takahara H, Kizawa K, Thompson PR, Ite K, Kitanishi K, Unno M. Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. Arch Biochem Biophys. 2021 Sep 15;708:108911. doi: 10.1016/j.abb.2021.108911. Epub 2021 May 7. PubMed PMID: 33971157.

select

Mondal S, Thompson PR. Chemical biology of protein citrullination by the protein A arginine deiminases. Curr Opin Chem Biol. 2021 Aug;63:19-27. doi: 10.1016/j.cbpa.2021.01.010. Epub 2021 Mar 4. Review. PubMed PMID: 33676233; PubMed Central PMCID: PMC8384633.

select

Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 Aug;102:70-84. doi: 10.1016/j.matbio.2021.07.001. Epub 2021 Jul 15. PubMed PMID: 34274450; PubMed Central PMCID: PMC8502204.

select

Young CH, Snow B, DeVore SB, Mohandass A, Nemmara VV, Thompson PR, Thyagarajan B, Navratil AM, Cherrington BD. Progesterone stimulates histone citrullination to increase IGFBP1 expression in uterine cells. Reproduction. 2021 Jul 8;162(2):117-127. doi: 10.1530/REP-21-0132. PubMed PMID: 34034233; PubMed Central PMCID: PMC8284904.

select

Loring HS, Czech VL, Icso JD, O'Connor L, Parelkar SS, Byrne AB, Thompson PR. A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration. Elife. 2021 Jun 29;10. doi: 10.7554/eLife.66694. PubMed PMID: 34184985; PubMed Central PMCID: PMC8266388.

select

Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszlán G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 Jun 23;12(1):3910. doi: 10.1038/s41467-021-24178-6. PubMed PMID: 34162877; PubMed Central PMCID: PMC8222335.

select

Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AVF, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal VJ, Carter AB, Antony VB. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med. 2021 Mar 17;13(585). doi: 10.1126/scitranslmed.aba2927. PubMed PMID: 33731433; PubMed Central PMCID: PMC8594069.

select

Sodré FMC, Bissenova S, Bruggeman Y, Tilvawala R, Cook DP, Berthault C, Mondal S, Callebaut A, You S, Scharfmann R, Mallone R, Thompson PR, Mathieu C, Buitinga M, Overbergh L. Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice. Diabetes. 2021 Feb;70(2):516-528. doi: 10.2337/db20-0421. Epub 2020 Nov 17. PubMed PMID: 33203696; PubMed Central PMCID: PMC7881854.

select

Lockbaum GJ, Reyes AC, Lee JM, Tilvawala R, Nalivaika EA, Ali A, Kurt Yilmaz N, Thompson PR, Schiffer CA. Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188. Viruses. 2021 Jan 25;13(2). doi: 10.3390/v13020174. PubMed PMID: 33503819; PubMed Central PMCID: PMC7911568.

select

Mondal S, Wang S, Zheng Y, Sen S, Chatterjee A, Thompson PR. Site-specific incorporation of citrulline into proteins in mammalian cells. Nat Commun. 2021 Jan 4;12(1):45. doi: 10.1038/s41467-020-20279-w. PubMed PMID: 33398026; PubMed Central PMCID: PMC7782748.

select

Tian Y, Qu S, Alam HB, Williams AM, Wu Z, Deng Q, Pan B, Zhou J, Liu B, Duan X, Ma J, Mondal S, Thompson PR, Stringer KA, Standiford TJ, Li Y. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis. JCI Insight. 2020 Oct 15;5(20). doi: 10.1172/jci.insight.138873. PubMed PMID: 33055424; PubMed Central PMCID: PMC7605547.

select

Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 Sep 25;369(6511):1633-1637. doi: 10.1126/science.abb9818. Epub 2020 Aug 20. PubMed PMID: 32820063; PubMed Central PMCID: PMC8744141.

select

Loring HS, Parelkar SS, Mondal S, Thompson PR. Identification of the first noncompetitive SARM1 inhibitors. Bioorg Med Chem. 2020 Sep 15;28(18):115644. doi: 10.1016/j.bmc.2020.115644. Epub 2020 Jul 17. PubMed PMID: 32828421; PubMed Central PMCID: PMC7443514.

select

Wu Z, Deng Q, Pan B, Alam HB, Tian Y, Bhatti UF, Liu B, Mondal S, Thompson PR, Li Y. Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock. Inflammation. 2020 Aug;43(4):1436-1445. doi: 10.1007/s10753-020-01221-0. PubMed PMID: 32239392; PubMed Central PMCID: PMC7384922.

select

Li G, Young CH, Snow B, Christensen AO, Demoruelle MK, Nemmara VV, Thompson PR, Rothfuss HM, Cherrington BD. Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome. Int J Mol Sci. 2020 Apr 10;21(7). doi: 10.3390/ijms21072634. PubMed PMID: 32290104; PubMed Central PMCID: PMC7177251.

select

Loring HS, Icso JD, Nemmara VV, Thompson PR. Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1. Biochemistry. 2020 Mar 3;59(8):933-942. doi: 10.1021/acs.biochem.9b01078. Epub 2020 Feb 17. PubMed PMID: 32049506; PubMed Central PMCID: PMC7085114.

select

Uysal-Onganer P, MacLatchy A, Mahmoud R, Kraev I, Thompson PR, Inal JM, Lange S. Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines. Int J Mol Sci. 2020 Feb 22;21(4). doi: 10.3390/ijms21041495. PubMed PMID: 32098295; PubMed Central PMCID: PMC7073130.

select

Salinger AJ, Dubuke ML, Carmona-Rivera C, Maurais AJ, Shaffer SA, Weerapana E, Thompson PR, Kaplan MJ. Technical comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis". Sci Immunol. 2020 Jan 31;5(43). doi: 10.1126/sciimmunol.aax5672. PubMed PMID: 32005680; PubMed Central PMCID: PMC7043321.

select

Carmona-Rivera C, Carlucci PM, Moore E, Lingampalli N, Uchtenhagen H, James E, Liu Y, Bicker KL, Wahamaa H, Hoffmann V, Catrina AI, Thompson PR, Buckner JH, Robinson WH, Fox DA, Kaplan MJ. Erratum for Research Article "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis" by C. Carmona-Rivera, P. M. Carlucci, E. Moore, N. Lingampalli, H. Uchtenhagen, E. James, Y. Liu, K. L. Bicker, H. Wahamma, V. Hoffman, A. I. Catrina, P. Thompson, J. H. Buckner, W. H. Robinson, D. A. Fox, M. J. Kaplan. Sci Immunol. 2020 Jan 31;5(43). doi: 10.1126/sciimmunol.aaz9319. PubMed PMID: 32005681; PubMed Central PMCID: PMC7228189.

select

Loring HS, Thompson PR. Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases. Cell Chem Biol. 2020 Jan 16;27(1):1-13. doi: 10.1016/j.chembiol.2019.11.002. Epub 2019 Nov 21. Review. PubMed PMID: 31761689; PubMed Central PMCID: PMC6980728.

select

Tilvawala R, Thompson PR. Peptidyl arginine deiminases: detection and functional analysis of protein citrullination. Curr Opin Struct Biol. 2019 Dec;59:205-215. doi: 10.1016/j.sbi.2019.01.024. Epub 2019 Mar 1. Review. PubMed PMID: 30833201; PubMed Central PMCID: PMC6717693.

select

Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CL, Shelef MA, Weerapana E, Thompson PR, Ho IC. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019 Nov 14;4(22). doi: 10.1172/jci.insight.129687. PubMed PMID: 31723060; PubMed Central PMCID: PMC6948856.

select

Li F, Miao L, Xue T, Qin H, Mondal S, Thompson PR, Coonrod SA, Liu X, Zhang X. Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells. J Exp Clin Cancer Res. 2019 Oct 10;38(1):414. doi: 10.1186/s13046-019-1404-8. PubMed PMID: 31601253; PubMed Central PMCID: PMC6785896.

select

Mondal S, Gong X, Zhang X, Salinger AJ, Zheng L, Sen S, Weerapana E, Zhang X, Thompson PR. Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors. Angew Chem Int Ed Engl. 2019 Sep 2;58(36):12476-12480. doi: 10.1002/anie.201906334. Epub 2019 Aug 1. PubMed PMID: 31276611; PubMed Central PMCID: PMC6713606.

select

Cau L, Takahara H, Thompson PR, Serre G, Méchin MC, Simon M. Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis. J Invest Dermatol. 2019 Sep;139(9):1889-1897.e4. doi: 10.1016/j.jid.2019.02.026. Epub 2019 Mar 13. PubMed PMID: 30878672; PubMed Central PMCID: PMC6708725.

select

Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury. Circ Res. 2019 Aug 16;125(5):507-519. doi: 10.1161/CIRCRESAHA.118.314571. Epub 2019 Jun 28. PubMed PMID: 31248335; PubMed Central PMCID: PMC6697196.

select

Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt RE, Coonrod SA, Thompson PR, Lerch MM, Bossaller L. Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1β Maturation and ASC Speck Formation in Macrophages. J Immunol. 2019 Aug 15;203(4):795-800. doi: 10.4049/jimmunol.1800720. Epub 2019 Jul 10. PubMed PMID: 31292215; PubMed Central PMCID: PMC6690178.

select

Zheng L, Nagar M, Maurais AJ, Slade DJ, Parelkar SS, Coonrod SA, Weerapana E, Thompson PR. Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2. Biochemistry. 2019 Jul 9;58(27):3042-3056. doi: 10.1021/acs.biochem.9b00225. Epub 2019 Jun 27. PubMed PMID: 31243954; PubMed Central PMCID: PMC6691507.

select

Sen S, Mondal S, Zheng L, Salinger AJ, Fast W, Weerapana E, Thompson PR. Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase. ACS Chem Biol. 2019 Apr 19;14(4):613-618. doi: 10.1021/acschembio.9b00211. Epub 2019 Apr 5. PubMed PMID: 30933557; PubMed Central PMCID: PMC6644700.